Articles

Correlation of sacroiliitis inflammatory change with MRI

Authors: Oliver Fitzgerald

Development of memory

Authors: Axel Nogai

metaRegister of Controlled Trials

Authors: Sarah Burrows

NFATp represses chondrogenesis

Authors: Mark Bolton

Apoptosis and p53 expression in rat adjuvant arthritis

The kinetics of apoptosis and the apoptosis-regulating gene p53 in adjuvant arthritis (AA) were investigated to assess the value of the AA rat model for testing apoptosis-inducing therapies. Very few terminal deo...

Authors: Paul P Tak, Maartje S Klapwijk, Sophie FM Broersen, Deliana A van de Geest, Marieke Overbeek and Gary S Firestein

PPAR? negatively regulates T cell function

Authors: Andy Clark

Information and services for the arthritis community

Authors: JC Lyford BSc

Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue

Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA express...

Authors: Rosemary O'Hara, Evelyn P Murphy, Alexander S Whitehead, Oliver FitzGerald and Barry Bresnihan

B cells in rheumatoid arthritis

Normally the immune response is restricted to the peripheral secondary lymphoid organs. However, additional ectopic lymphoid tissue may develop at chronic sites of inflammation. In the synovium of rheumatoid a...

Authors: Hye-Jung Kim and Claudia Berek

Risk for rheumatic disease in relation to ethnicity and admixture

Risk of systemic lupus erythematosus (SLE) is high in west Africans compared with Europeans, and risk of rheumatoid arthritis (RA) is high in Native Americans compared with Europeans. These differences are not...

Authors: Mariam Molokhia and Paul McKeigue

A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?

Dominant paradigms for the understanding of rheumatoid arthritis (RA) pathogenesis have changed over the years. A predominant role of B lymphocytes, and perhaps of the rheumatoid factor they produced, was init...

Authors: Christophe Benoist and Diane Mathis

The role of VEGF in bone formation

Authors: Ewa Paleolog

Mice deficient in secreted IgM develop autoimmune disease

Authors: Cheryl Smythe

CD25⁺ CD4⁺immunoregulatory T cells

Authors: Sarah Parry

CD40 ligand blockade

Authors: Frances Williams

T cell gene expression profiles

Authors: Gerry Wilson

What can we do about osteoarthritis?

Osteoarthritis is complex in genetics, pathogenesis, monitoring and treatment. Current treatment of osteoarthritis does not influence progression. Much could be gained by more effective 'low-tech-low-cost' tre...

Authors: L Stefan Lohmander

Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy...

Authors: Raphaela Goldbach-Mansky, Jennifer M Lee, Joseph M Hoxworth, David Smith II, Paul Duray, H Ralph Schumacher Jr, Cheryl H Yarboro, John Klippel, David Kleiner and Hani S El-Gabalawy

Death, autoantigen modifications, and tolerance

Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The me...

Authors: Paul J Utz,, Timothy J Gensler and Paul Anderson

A new model for rheumatoid arthritis?

A chance observation has led to the development of a new murine model for inflammatory arthritis. Arthritis is induced, and transferred, by T-cell-dependent antibodies to glucose-6-phosphate isomerase. This en...

Authors: Hugh McDevitt

Association of MHC Class II and CD40

Authors: Frances Williams

Specificity of T cells in synovial fluid: high frequencies of CD8⁺ T cells that are specific for certain viral epitopes

CD8⁺ T cells dominate the lymphocyte population insynovial fluid in chronic inflammatory arthritis. It is known that theseCD8⁺ T cells are often clonally or oligoclonally expanded, but theirspecificity and their ...

Authors: Linda C Tan, Alastair G Mowat, Chrysoula Fazou, Tim Rostron, Helen Roskell, P Rod Dunbar, Claire Tournay, François Romagné, Marie-Alix Peyrat, Elisabeth Houssaint, Marc Bonneville, Alan B Rickinson, Andrew J McMichael and Margaret FC Callan

Whole genome scan of a murine model of RA

Authors: Ali Hajeer

Gene therapy with NF-κB decoy oligodeoxynucleotides in arthritis

Authors: Hanna Dreja

YKL-40 (HCgp-39) in giant cell arteritis

Authors: Frances Hall

IL-1 receptor antagonist-deficient mice develop autoimmune arthritis

Authors: Cheryl Smythe

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Authors: S Louis Bridges

Oncostatin M: a key cytokine in arthritis

Authors: Douglas Veale

Mouse Models at The Jackson Laboratory

Authors: JC Lyford

IL-4 gene therapy in arthritis

Authors: David Gould

A one-stop information source for professionals and patients

Authors: JC Lyford

Monocyte chemoattractant protein 1 promotes autoimmune injury

Authors: Diane Marshall

TANK-binding kinase 1 activates NF-?B

Authors: Andy Finch

Bone anabolic effects of statins

Authors: Mike Rogers

Cytokine therapy for proteoglycan-induced arthritis

Authors: Frances Hall

NK T cells in rheumatoid arthritis

Authors: Martin Rudwaleit

High dose chemotherapy followed by autologous stem cell transplantation in the treatment of patients with refractory RA

Authors: Robert Verburg

Organogenic role of B lymphocytes in mucosal immunity

Authors: Thomas Dorner

Complement factor H deficiency and atypical HUS

Authors: Tim Vyse

Bcl-2 and anti-DNA antibodies

Authors: Chaim Putterman

Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation

Cytokines play a critical role in the normal development and function of the immune system. On the other hand, many rheumatologic diseases are characterized by poorly controlled responses to or dysregulated pr...

Authors: Robert A Ortmann, Tammy Cheng, Roberta Visconti, David M Frucht and John J O'Shea

IFN-γ production in response to in vitro stimulation with collagen type II in rheumatoid arthritis is associated with HLA-DRB1^*0401 and HLA-DQ8

IFN-γ was measured in supernatants after in vitro stimulation of peripheral blood mononuclear cells with collagen type II (CII), purified protein derivative or influenza virus. IFN-γ production in response to CII...

Authors: Louise Berg, Johan Rönnelid, Carani B Sanjeevi, Jon Lampa and Lars Klareskog

Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion

Mast cell (MC) activation in the rheumatoid lesion provides numerous mediators that contribute to inflammatory and degradative processes, especially at sites of cartilage erosion. MC activation in rheumatoid s...

Authors: David E Woolley and Lynne C Tetlow

Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications

Rheumatoid arthritis represents an excellent model in which to gain insights into the local and systemic effects of joint inflammation on skeletal tissues. Three forms of bone disease have been described in rh...

Authors: Steven R Goldring and Ellen M Gravallese

Joint-specific and systemic autoreactivity in the development of inflammatory arthritis

Authors: Lars Fugger

The Arthritis Research non-peer-review depository

Authors: Peter E Lipsky and Ravinder N Maini

Perlecan is essential for cartilage development

Authors: Mark Bolton

Bystander suppression in an auto-immune disease model

Authors: Sarah Parry

Fc?RIIA polymorphism and anti-C1q(CLR) in SLE

Authors: Carrock Sewell

Autoimmunity to a ubiquitous glycoprotein targets the synovial joint

Authors: Andrew Cope