Table 2 Population attributable and average attributable fractions for HU risk exposures
| Cohort 1 (US-based) | Cohort 2 (UK-based) | Cohort 3 (UK-based) | Gout cohort (UK-based) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | PAF (95% CI) | AAF (95% CI) | OR (95% CI) | PAF (95% CI) | AAF (95% CI) | OR (95% CI) | PAF (95% CI) | AAF (95% CI) | OR (95% CI) | PAF (95% CI) | AAF (95% CI) | |
| Sex - male | 6.2 (5.4; 7.0) | 64.3 (64.6; 67.8) | 29.8 (29.2; 30.3) | 8.2 (7.5; 8.9) | 75.6 (74.6; 76.5) | 30.9 (30.2; 31.6) | 7.5 (7.3; 7.8) | 73.4 (73.0; 73.8) | 30.8 (30.2; 31.5) | 4.9 (3.7; 6.6) | 76.7 (69.9; 81.7) | 30.2 (29.7; 30.6) |
| BMI ≥25 kg/m2 | 3.4 (3.0; 3.8) | 59.2 (55.8; 62.2) | 23.5 (23.1; 24.0) | 4.2 (3.8; 4.6) | 68.6 (66.2; 70.8) | 26.2 (25.5; 26.8) | 3.8 (3.6; 3.9) | 66.4 (65.4; 67.3) | 25.8 (25.2; 26.4) | 2.1 (1.6; 2.7) | 48.8 (36.4; 58.4) | 14.2 (14.0; 14.2) |
|
SLC2A9, rs12498742 A-allele present | 2.4 (1.8; 3.2) | 56.6 (43.8; 66.3) | 22.0 (21.6; 22.4) | 2.9 (2.4; 3.5) | 63.8 (56.2; 70.0) | 23.5 (22.9; 0.24) | 2.7 (2.5; 2.9) | 61.7 (58.8; 64.3) | 23.1 (22.6; 23.7) | 1.9 (1.2; 3.2) | 47.8 (16.2; 67.3) | 13.5 (13.3; 13.8) |
| Diet non-adherence | 1.3 (0.6; 2.4)# | 20.3 (54.6; 58.8)# | 6.3 (6.2; 6.5) # | 1.3 (1.2; 1.5) # | 23.6 (12.7; 33.0) # | 7.1 (6.9; 7.3) # | 1.3 (1.2; 1.4) * | 21.4 (8.2; 24.4)* | 6.5 (6.3; 6.7)* | 1.2 (0.9; 1.4)* | 11.8 (−7.3; 27.2)* | 2.7 (2.6; 2.7)* |
| Alcohol ≥1 drink/week | 1.1 (1.0; 1.2) | 5.2 (−0.1; 10.0) | 1.5 (1.4; 1.5) | 1.3 (1.2; 1.4) | 19.5 (14.2; 24.3) | 5.7 (5.6; 5.9) | 1.3 (1.3; 1.4) | 19.4 (17.5; 21.2) | 5.9 (5.7; 6.0) | 1.1 (0.9; 1.4) | 10.0 (−5.8; 23.1) | 2.2 (2.2; 2.3) |
| On diuretic therapy | 4.8 (4.2; 5.5) | 21.1 (20.3; 21.9) | 8.7 (8.6; 8.9) | 4.2 (3.8; 4.6) | 15.1 (14.6; 15.5) | 4.8 (4.7; 5.0) | 4.3 (4.2; 4.5) | 17.1 (16.9; 17.3) | 5.8 (5.6; 5.9) | 1.7 (1.4; 2.0) | 6.4 (4.6; 7.9) | 1.8 (1.7; 1.8) |
| Age ≥ 50 years | 1.3 (1.1; 1.4) | 15.1 (8.7; 20.9) | 4.7 (4.6; 4.8) | 1.0 (0.9; 1.1) | 0.4 (−6.4; 6.6) | 0.1 (0.1; 0.1) | 1.0 (1.0; 1.0) | 0.2 (−2.4; 2.7) | 0.1 (0.1; 0.1) | ^ | ^ | ^ |
| Not treated with urate-lowering therapy | ^ | ^ | ^ | ^ | ^ | ^ | ^ | ^ | ^ | 21.8 (18.9; 25.1) | 63.2 (62.7; 63.6) | 33.3 (32.8; 33.7) |