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| |
ΔMethylation
|
ΔHydroxymethylation
|
|---|
| |
Biomarkers
|
B (SE)
|
β
|
p
|
B (SE)
|
β
|
p
|
|---|
|
1
|
Δ(hydroxy)methylation
|
− 0.50 (0.60)
|
− 0.07
|
0.403
|
− 9.32 (19.40)
|
− 0.04
|
0.632
|
|
2
|
Δ(hydroxy)methylation
|
− 0.68 (0.51)
|
− 0.09
|
0.182
|
− 1.55 (16.35)
|
− 0.01
|
0.925
|
| |
DAS28
|
− 0.51 (0.07)
|
− 0.51
|
< 0.001
|
− 0.52 (0.07)
|
− 0.51
|
< 0.001
|
| |
Erythrocyte folate (nmol/L)
|
− 1.00 × 10−3 (2.00 × 10−4)
|
− 0.15
|
0.027
|
− 1.00 × 10−3 (2.00 × 10−4)
|
− 0.16
|
0.024
|
| |
BMI (kg/m2)
|
0.05 (0.03)
|
0.19
|
0.005
|
0.04 (0.02)
|
0.18
|
0.008
|
| |
Age (years)
|
0.01 (0.01)
|
0.10
|
0.134
|
0.01 (0.01)
|
0.11
|
0.130
|
| |
Sex
| |
–
| |
0.20 (0.17)
|
0.08
|
0.240
|
| |
Smoking (current)
|
0.29 (0.17)
|
0.11
|
0.086
|
0.28 (0.17)
|
0.11
|
0.101
|
| |
ACPA status (positive)
| |
–
| | |
–
| |
| |
Observations
| |
163
| | |
161
| |
- Associations were tested using crude univariate models (1) and adjusted for confounders (2). Potential confounders were baseline DAS28 score, baseline erythrocyte folate levels (nmol/L), BMI (kg/m2), age (years), sex, smoking status (current smoker versus former + never smoker), and ACPA status. Only biomarkers that changed the effect size with > 10% were considered confounders. B beta coefficient, SE standard error, β standardized beta coefficient. p < 0.05 was considered significant
