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Organ system
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Toxicity
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Gastrointestinal
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Dyspepsia
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Esophagitis
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Gastroduodenal ulcers
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Ulcer complications (bleeding, perforation obstruction)
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Small bowel erosions and strictures
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Colitis
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Renal
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Sodium retention
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Weight gain and edema
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Hypertension
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Type IV renal tubular acidosis and hyperkalemia
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Acute renal failure
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Papillary necrosis
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Acute interstitial nephritis
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Accelerated chronic kidney disease
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Cardiovascular
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Heart failure
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Myocardial infarction
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Stroke
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Cardiovascular death
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Hepatic
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Elevated transaminases
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Asthma/allergic
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Aspirin-exacerbated respiratory diseasea (susceptible patients)
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Rash
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Hematologic
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Cytopenias
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Nervous
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Dizziness, confusion, drowsiness
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Seizures
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Aseptic meningitis
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Bone
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Delayed healing
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- Reprinted with permission from [1]. aReduced risk in cyclooxygenase-2-selective NSAIDs
